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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM50539818 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1979484 (CHEMBL4612619) | ||
| IC50 | 54±n/a nM | ||
| Citation |  Hansen, BB; Jepsen, TH; Larsen, M; Sindet, R; Vifian, T; Burhardt, MN; Larsen, J; Seitzberg, JG; Carnerup, MA; Jerre, A; Mølck, C; Lovato, P; Rai, S; Nasipireddy, VR; Ritzén, A Fragment-Based Discovery of Pyrazolopyridones as JAK1 Inhibitors with Excellent Subtype Selectivity. J Med Chem63:7008-7032 (2020) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
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| BDBM50539818 | |||
| n/a | |||
| Name | BDBM50539818 | ||
| Synonyms: | CHEMBL4648612 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C15H19N3O | ||
| Mol. Mass. | 257.3309 | ||
| SMILES | Cc1[nH]nc2[nH]c(=O)cc(C3CC4CCC3CC4)c12 |(14.47,-21.16,;14.94,-22.62,;14.03,-23.86,;14.94,-25.12,;16.41,-24.64,;17.75,-25.4,;19.08,-24.64,;20.42,-25.41,;19.08,-23.09,;17.75,-22.31,;17.75,-20.77,;16.42,-20.01,;16.43,-18.46,;17.77,-17.7,;19.09,-18.48,;19.09,-20.01,;17.55,-20,;17.97,-18.46,;16.41,-23.09,)| | ||
| Structure | 
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