Reaction Details | |||
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Target | Tyrosine-protein kinase JAK2 | ||
Ligand | BDBM50539839 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1979487 (CHEMBL4612622) | ||
IC50 | 89±n/a nM | ||
Citation | Hansen, BB; Jepsen, TH; Larsen, M; Sindet, R; Vifian, T; Burhardt, MN; Larsen, J; Seitzberg, JG; Carnerup, MA; Jerre, A; Mølck, C; Lovato, P; Rai, S; Nasipireddy, VR; Ritzén, A Fragment-Based Discovery of Pyrazolopyridones as JAK1 Inhibitors with Excellent Subtype Selectivity. J Med Chem63:7008-7032 (2020) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK2 | |||
Name: | Tyrosine-protein kinase JAK2 | ||
Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
Type: | Protein | ||
Mol. Mass.: | 130684.68 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O60674 | ||
Residue: | 1132 | ||
Sequence: |
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BDBM50539839 | |||
n/a | |||
Name | BDBM50539839 | ||
Synonyms: | CHEMBL4638030 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H25N5O2 | ||
Mol. Mass. | 367.4448 | ||
SMILES | Cc1[nH]nc2[nH]c(=O)cc([C@H]3CC[C@H](CC(=O)N4CCC(C4)C#N)CC3)c12 |r,wU:10.9,wD:13.13,(20.46,-18.84,;20.93,-20.3,;20.02,-21.55,;20.93,-22.8,;22.41,-22.33,;23.74,-23.09,;25.07,-22.33,;26.41,-23.1,;25.07,-20.78,;23.74,-20,;23.75,-18.45,;22.42,-17.69,;22.43,-16.14,;23.77,-15.38,;23.77,-13.84,;22.44,-13.06,;21.11,-13.82,;22.45,-11.52,;23.7,-10.62,;23.23,-9.16,;21.69,-9.15,;21.21,-10.61,;20.81,-7.9,;19.91,-6.65,;25.09,-16.15,;25.09,-17.69,;22.41,-20.78,)| | ||
Structure |