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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK3 | ||
| Ligand | BDBM50539833 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1979488 (CHEMBL4612623) | ||
| IC50 | 91±n/a nM | ||
| Citation |  Hansen, BB; Jepsen, TH; Larsen, M; Sindet, R; Vifian, T; Burhardt, MN; Larsen, J; Seitzberg, JG; Carnerup, MA; Jerre, A; Mølck, C; Lovato, P; Rai, S; Nasipireddy, VR; Ritzén, A Fragment-Based Discovery of Pyrazolopyridones as JAK1 Inhibitors with Excellent Subtype Selectivity. J Med Chem63:7008-7032 (2020) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK3 | |||
| Name: | Tyrosine-protein kinase JAK3 | ||
| Synonyms: | JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase | ||
| Type: | Protein | ||
| Mol. Mass.: | 125111.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P52333 | ||
| Residue: | 1124 | ||
| Sequence: |
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| BDBM50539833 | |||
| n/a | |||
| Name | BDBM50539833 | ||
| Synonyms: | CHEMBL4632766 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H19F2N3O3 | ||
| Mol. Mass. | 351.3479 | ||
| SMILES | Cc1[nH]nc2[nH]c(=O)cc([C@H]3CC[C@@H](CC3)OC(=O)[C@@H]3CC3(F)F)c12 |r,wU:10.9,19.19,wD:13.16,(27.12,-30.36,;27.6,-31.82,;26.69,-33.06,;27.6,-34.31,;29.07,-33.84,;30.4,-34.6,;31.73,-33.84,;33.06,-34.61,;31.73,-32.3,;30.4,-31.51,;30.41,-29.97,;29.08,-29.21,;29.09,-27.66,;30.42,-26.9,;31.75,-27.68,;31.75,-29.21,;30.43,-25.36,;29.11,-24.59,;27.77,-25.35,;29.11,-23.05,;29.88,-21.72,;28.34,-21.71,;26.8,-21.71,;27.57,-20.38,;29.07,-32.3,)| | ||
| Structure | 
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