| Reaction Details |
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 | Report a problem with these data |
| Target | Trypanothione reductase |
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| Ligand | BDBM50096494 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_225789 |
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| Ki | 10300±n/a nM |
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| Citation |  Li, Z; Fennie, MW; Ganem, B; Hancock, MT; Kobaslija, M; Rattendi, D; Bacchi, CJ; O'Sullivan, MC Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents. Bioorg Med Chem Lett11:251-4 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Trypanothione reductase |
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| Name: | Trypanothione reductase |
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| Synonyms: | N(1),N(8)-bis(glutathionyl)spermidine reductase | TPR | TR | TYTR_TRYCR |
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| Type: | Homodimer; oxidoreductase |
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| Mol. Mass.: | 53868.26 |
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| Organism: | Trypanosoma cruzi |
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| Description: | n/a |
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| Residue: | 492 |
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| Sequence: | MMSKIFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVGCVP
KKLMVTGAQYMEHLRESAGFGWEFDRTTLRAEWKKLIAVKDEAVLNINKSYEEMFRDTEG
LEFFLGWGSLESKNVVNVRESADPASAVKERLETENILLASGSWPHMPNIPGIEHCISSN
EAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREELT
KQLTANGIQILTKENPAKVELNADGSKSVTFESGKKMDFDLVMMAIGRSPRTKDLQLQNA
GVMIKNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTVFGTNPRKTDHT
RVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPLMHNISGSKYKTFVAKIITNHS
DGTVLGVHLLGDNAPEIIQGVGICLKLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVK
GEKMEKPSEASL
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| BDBM50096494 |
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| n/a |
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| Name | BDBM50096494 |
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| Synonyms: | CHEMBL310207 | N,N'-Bis-{3-[bis-(3-phenyl-propyl)-amino]-propyl}-N,N'-bis-(3-phenyl-propyl)-butane-1,4-diamine |
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| Type | Small organic molecule |
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| Emp. Form. | C64H86N4 |
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| Mol. Mass. | 911.3944 |
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| SMILES | C(CCN(CCCN(CCCc1ccccc1)CCCc1ccccc1)CCCc1ccccc1)CN(CCCN(CCCc1ccccc1)CCCc1ccccc1)CCCc1ccccc1 |
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| Structure | 
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