| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 1 |
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| Ligand | BDBM50430159 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1981892 (CHEMBL4615154) |
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| IC50 | 77±n/a nM |
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| Citation |  Tian, M; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Müller, CE Discovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X1 Receptor Antagonists. J Med Chem63:6164-6178 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 1 |
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| Name: | P2X purinoceptor 1 |
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| Synonyms: | ATP receptor | P2RX1 | P2RX1_HUMAN | P2X1 | Purinergic receptor | Purinergic, P2X |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44992.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purinergic, P2X 0 HUMAN::P51575 |
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| Residue: | 399 |
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| Sequence: | MARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSG
LISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEH
PEGGICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLR
EAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESG
QNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNLSPGFNFRFARHFVEN
GTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKR
HYYKQKKFKYAEDMGPGAAERDLAATSSTLGLQENMRTS
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| BDBM50430159 |
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| n/a |
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| Name | BDBM50430159 |
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| Synonyms: | CHEMBL461542 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H9F6NO2 |
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| Mol. Mass. | 349.2279 |
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| SMILES | Oc1ccccc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F |
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| Structure | 
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