| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific histone demethylase 1A |
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| Ligand | BDBM50540640 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1982515 (CHEMBL4615777) |
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| IC50 | 0.140000±n/a nM |
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| Citation |  Romussi, A; Cappa, A; Vianello, P; Brambillasca, S; Cera, MR; Dal Zuffo, R; Fagą, G; Fattori, R; Moretti, L; Trifirņ, P; Villa, M; Vultaggio, S; Cecatiello, V; Pasqualato, S; Dondio, G; So, CWE; Minucci, S; Sartori, L; Varasi, M; Mercurio, C Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models. ACS Med Chem Lett11:754-759 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific histone demethylase 1A |
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| Name: | Lysine-specific histone demethylase 1A |
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| Synonyms: | AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 92901.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60341 |
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| Residue: | 852 |
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| Sequence: | MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP
RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY
REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQ
SRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA
PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSF
GMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKC
PLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE
KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV
KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFAN
ATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGC
EVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLN
KVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPI
TPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQA
TPGVPAQQSPSM
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| BDBM50540640 |
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| n/a |
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| Name | BDBM50540640 |
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| Synonyms: | CHEMBL4641768 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H36N4OS |
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| Mol. Mass. | 476.677 |
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| SMILES | CCCc1cn(CCCc2ccc(OCC3CCNCC3)cc2)c(n1)-c1cc2sccc2n1C |
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| Structure | 
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