Ki Summary

Reaction Details

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Target

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Ligand

BDBM50097053

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_208114

IC50

30000±n/a nM

Citation

Dini, C; Drochon, N; Feteanu, S; Guillot, JC; Peixoto, C; Aszodi, J Synthesis of analogues of the O-beta-D-ribofuranosyl nucleoside moiety of liposidomycins. Part 1: contribution of the amino group and the uracil moiety upon the inhibition of MraY. Bioorg Med Chem Lett11:529-31 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Name:

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Synonyms:

MRAY_ECOLI | Phospho-N-acetylmuramoyl-pentapeptide-transferase/UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | mraY | murX

Type:

PROTEIN

Mol. Mass.:

39889.38

Organism:

Escherichia coli (strain K12)

Description:

ChEMBL_1454117

Residue:

360

Sequence:

MLVWLAEHLVKYYSGFNVFSYLTFRAIVSLLTALFISLWMGPRMIAHLQKLSFGQVVRND
GPESHFSKRGTPTMGGIMILTAIVISVLLWAYPSNPYVWCVLVVLVGYGVIGFVDDYRKV
VRKDTKGLIARWKYFWMSVIALGVAFALYLAGKDTPATQLVVPFFKDVMPQLGLFYILLA
YFVIVGTGNAVNLTDGLDGLAIMPTVFVAGGFALVAWATGNMNFASYLHIPYLRHAGELV
IVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGIIAVLLRQEFLLVIMGGVFVVE
TLSVILQVGSFKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLMLVLIGLATLKVR

BDBM50097053

n/a

Name

BDBM50097053

Synonyms:

1-[5-[3,4-dihydroxy-5-iminomethylaminomethyl-(2R,3R,4R,5R)-tetrahydro-2-furanyloxymethyl]-3,4-dihydroxy-(2R,3R,4R,5R)-tetrahydro-2-furanyl]-1,2,3,4-tetrahydro-2,4-pyrimidinedione | CHEMBL147455

Type

Small organic molecule

Emp. Form.

C15H22N4O9

Mol. Mass.

402.3566

SMILES

O[C@@H]1[C@@H](CNC=N)O[C@@H](OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@@H]1O

Structure