Ki Summary

Reaction Details

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Target

Beta-glucuronidase

Ligand

BDBM50185127

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1983573 (CHEMBL4616979)

IC50

97210±n/a nM

Citation

Awolade, P; Cele, N; Kerru, N; Gummidi, L; Oluwakemi, E; Singh, P Therapeutic significance of ?-glucuronidase activity and its inhibitors: A review. Eur J Med Chem187:0 (2020) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Beta-glucuronidase

Name:

Beta-glucuronidase

Synonyms:

BGLR_RAT | Gus | Gusb

Type:

PROTEIN

Mol. Mass.:

74794.72

Organism:

Rattus norvegicus

Description:

ChEMBL_37581

Residue:

648

Sequence:

MSPRRSVCWFVLGQLLCSCAVALQGGMLFPKETPSRELKVLDGLWSFRADYSNNRLQGFE
KQWYRQPLRESGPTLDMPVPSSFNDITQEAELRNFIGWVWYEREAVLPQRWTQDTDRRVV
LRINSAHYYAVVWVNGIHVVEHEGGHLPFEADITKLVQSGPLTTFRVTIAINNTLTPYTL
PPGTIVYKTDPSMYPKGYFVQDISFDFFNYAGLHRSVVLYTTPTTYIDDITVTTDVDRDV
GLVNYWISVQGSDHFQLEVRLLDEDGKIVARGTGNEGQLKVPRAHLWWPYLMHEHPAYLY
SLEVTMTTPESVSDFYTLPVGIRTVAVTKSKFLINGKPFYFQGVNKHEDSDIRGRGFDWP
LLIKDFNLLRWLGANSFRTSHYPYSEEVLQLCDRYGIVVIDECPGVGIVLPQSFGNVSLR
HHLEVMDELVRRDKNHPAVVMWSVANEPVSSLKPAGYYFKTLIAHTKALDPTRPVTFVSN
TRYDADMGAPYVDVICVNSYLSWYHDYGHLEVIQLQLTSQFENWYKMYQKPIIQSEYGAD
AVSGLHEDPPRMFSEEYQTALLENYHLILDEKRKEYVIGELIWNFADFMTNQSPLRVTGN
KKGIFTRQRNPKMAAFILRERYWRIANETRGYGSVPRTQCMGSRPFTF

BDBM50185127

n/a

Name

BDBM50185127

Synonyms:

(3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl-2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid | 30-hydroxy-11,30-dioxoolean-12-en-3beta-yl (2-O-beta-D-glucopyranosyluronic acid)-alpha-D-glucopyranosiduronic acid | CHEMBL441687 | glycyrrhizic acid | glycyrrhizinic acid | glyzyrrhizin

Type

Small organic molecule

Emp. Form.

C42H62O16

Mol. Mass.

822.9321

SMILES

CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O)C(O)=O |r,t:18|

Structure