| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 |
|---|
| Ligand | BDBM50541412 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1984204 (CHEMBL4617610) |
|---|
| IC50 | 0.140000±n/a nM |
|---|
| Citation |  Dubowchik, GM; Conway, CM; Xin, AW Blocking the CGRP Pathway for Acute and Preventive Treatment of Migraine: The Evolution of Success. J Med Chem63:6600-6623 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 |
|---|
| Name: | Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 |
|---|
| Synonyms: | Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of EBI is 327200 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Calcitonin gene-related peptide type 1 receptor |
|---|
| Synonyms: | Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 52980.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16602 |
|---|
| Residue: | 461 |
|---|
| Sequence: | MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
|
|
|
|---|
| Component 2 |
| Name: | Receptor activity-modifying protein 1 |
|---|
| Synonyms: | Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 | RAMP1 | RAMP1_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 16992.80 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | EBI_100673 |
|---|
| Residue: | 148 |
|---|
| Sequence: | MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWG
RTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILY
PFIVVPITVTLLVTALVVWQSKRTEGIV
|
|
|
|---|
| BDBM50541412 |
|---|
| n/a |
|---|
| Name | BDBM50541412 |
|---|
| Synonyms: | CHEMBL4644508 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C36H47ClF3N7O3 |
|---|
| Mol. Mass. | 718.252 |
|---|
| SMILES | CN1CCN(CC1)C1CCN(CC1)C(=O)[C@H](CC(=O)N1CCC(CC1)N1CCc2ccccc2NC1=O)Cc1cc(Cl)c(N)c(c1)C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
