| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbapenem-hydrolyzing beta-lactamase KPC |
|---|
| Ligand | BDBM50541449 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1984272 (CHEMBL4617678) |
|---|
| Ki | 21±n/a nM |
|---|
| Citation |  Hecker, SJ; Reddy, KR; Lomovskaya, O; Griffith, DC; Rubio-Aparicio, D; Nelson, K; Tsivkovski, R; Sun, D; Sabet, M; Tarazi, Z; Parkinson, J; Totrov, M; Boyer, SH; Glinka, TW; Pemberton, OA; Chen, Y; Dudley, MN Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-?-lactamases. J Med Chem63:7491-7507 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbapenem-hydrolyzing beta-lactamase KPC |
|---|
| Name: | Carbapenem-hydrolyzing beta-lactamase KPC |
|---|
| Synonyms: | BLKPC_KLEOX | Carbapenem-hydrolyzing beta-lactamase KPC-2 | bla | kpc | kpc2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 31116.99 |
|---|
| Organism: | n/a |
|---|
| Description: | Q848S6 |
|---|
| Residue: | 293 |
|---|
| Sequence: | MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYR
AEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAE
LSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTS
SPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVY
GTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ
|
|
|
|---|
| BDBM50541449 |
|---|
| n/a |
|---|
| Name | BDBM50541449 |
|---|
| Synonyms: | CHEMBL4636953 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H13BN4O5S2 |
|---|
| Mol. Mass. | 380.207 |
|---|
| SMILES | Nc1nnc(SCC(=O)N[C@H]2Cc3cccc(C(O)=O)c3OB2O)s1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
