| Reaction Details |
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 | Report a problem with these data |
| Target | Thrombospondin-1 |
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| Ligand | BDBM50541833 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1985421 (CHEMBL4618827) |
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| IC50 | 2.9±n/a nM |
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| Citation |  Suto, MJ; Gupta, V; Mathew, B; Zhang, W; Pallero, MA; Murphy-Ullrich, JE Identification of Inhibitors of Thrombospondin 1 Activation of TGF-?. ACS Med Chem Lett11:1130-1136 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thrombospondin-1 |
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| Name: | Thrombospondin-1 |
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| Synonyms: | Glycoprotein G | THBS1 | TSP | TSP1 | TSP1_HUMAN | Thrombospondin-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 129327.50 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119903 |
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| Residue: | 1170 |
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| Sequence: | MGLAWGLGVLFLMHVCGTNRIPESGGDNSVFDIFELTGAARKGSGRRLVKGPDPSSPAFR
IEDANLIPPVPDDKFQDLVDAVRAEKGFLLLASLRQMKKTRGTLLALERKDHSGQVFSVV
SNGKAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELD
VPIQSVFTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGTTPEDILRNKGCSSSTSVLL
TLDNNVVNGSSPAIRTNYIGHKTKDLQAICGISCDELSSMVLELRGLRTIVTTLQDSIRK
VTEENKELANELRRPPLCYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSN
ATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGSSVQT
RTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARE
TKACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQI
CNKQDCPIDGCLSNPCFAGVKCTSYPDGSWKCGACPPGYSGNGIQCTDVDECKEVPDACF
NHNGEHRCENTDPGYNCLPCPPRFTGSQPFGQGVEHATANKQVCKPRNPCTDGTHDCNKN
AKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPN
LPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYN
HNPDQADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEH
NPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDN
DGIPDDKDNCRLVPNPDQKDSDGDGRGDACKDDFDHDSVPDIDDICPENVDISETDFRRF
QMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDD
DYAGFVFGYQSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNAL
WHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYD
KTYAGGRLGLFVFSQEMVFFSDLKYECRDP
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| BDBM50541833 |
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| n/a |
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| Name | BDBM50541833 |
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| Synonyms: | CHEMBL4636492 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H37N5O5 |
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| Mol. Mass. | 415.5276 |
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| SMILES | CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](NC(C)=O)[C@@H](C)O |r| |
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| Structure | 
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