| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C zeta type |
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| Ligand | BDBM50542116 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1985963 (CHEMBL4619369) |
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| IC50 | 0.500000±n/a nM |
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| Citation |  Atobe, M; Serizawa, T; Yamakawa, N; Takaba, K; Nagano, Y; Yamaura, T; Tanaka, E; Tazumi, A; Bito, S; Ishiguro, M; Kawanishi, M Discovery of 4,6- and 5,7-Disubstituted Isoquinoline Derivatives as a Novel Class of Protein Kinase C ? Inhibitors with Fragment-Merging Strategy. J Med Chem63:7143-7162 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C zeta type |
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| Name: | Protein kinase C zeta type |
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| Synonyms: | KPCZ_HUMAN | PKC2 | PRKCZ | Protein Kinase C, zeta | Protein kinase C (PKC) | Protein kinase C iota type/zeta type | Protein kinase C zeta | Protein kinase C zeta (PKCζ) | Protein kinase C zeta type | Protein kinase C zeta type (PKC zeta) | Protein kinase C zeta type (PKCzeta) | nPKC-zeta |
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| Type: | Enzyme |
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| Mol. Mass.: | 67649.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 592 |
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| Sequence: | MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW
VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR
RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC
RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG
IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE
KHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEI
CIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP
EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF
LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT
DDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
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| BDBM50542116 |
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| n/a |
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| Name | BDBM50542116 |
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| Synonyms: | CHEMBL4646995 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N4 |
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| Mol. Mass. | 318.4155 |
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| SMILES | Nc1ccc(cc1)-c1cc(NC2CCCNC2)c2ccncc2c1 |
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| Structure | 
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