| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50542213 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1986246 (CHEMBL4619652) |
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| Kd | 38±n/a nM |
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| Citation |  Hassan, MM; Israelian, J; Nawar, N; Ganda, G; Manaswiyoungkul, P; Raouf, YS; Armstrong, D; Sedighi, A; Olaoye, OO; Erdogan, F; Cabral, AD; Angeles, F; Altintas, R; de Araujo, ED; Gunning, PT Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting. J Med Chem63:8634-8648 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50542213 |
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| n/a |
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| Name | BDBM50542213 |
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| Synonyms: | CHEMBL4641613 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15F3N2O3 |
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| Mol. Mass. | 352.3078 |
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| SMILES | CCN(C(=O)c1cccc(c1)C(F)(F)F)c1ccc(cc1)C(=O)NO |
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| Structure | 
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