| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 8 |
|---|
| Ligand | BDBM50542371 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1986731 (CHEMBL4620278) |
|---|
| Kd | 3.5±n/a nM |
|---|
| Citation |  Solum, E; Hansen, TV; Aesoy, R; Herfindal, L New CDK8 inhibitors as potential anti-leukemic agents - Design, synthesis and biological evaluation. Bioorg Med Chem28:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 8 |
|---|
| Name: | Cyclin-dependent kinase 8 |
|---|
| Synonyms: | CDK8 | CDK8_HUMAN | Cell division protein kinase 8 | Cyclin-Dependent Kinase 8 (CDK8) | Mediator complex subunit CDK8 | Mediator of RNA polymerase II transcription subunit CDK8 | Protein kinase K35 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 53300.21 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P49336 |
|---|
| Residue: | 464 |
|---|
| Sequence: | MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS
MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP
VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH
KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT
EEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTS
DYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
|
|
|
|---|
| BDBM50542371 |
|---|
| n/a |
|---|
| Name | BDBM50542371 |
|---|
| Synonyms: | CHEMBL4637601 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H40N2 |
|---|
| Mol. Mass. | 428.652 |
|---|
| SMILES | [H][C@@]12CC=C(c3cccc4cnccc34)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@@H](CC[C@]12C)N(C)C |r,t:3| |
|---|
| Structure | 
|
|---|
Search and Browse
