| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50099546 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_141778 |
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| IC50 | 15±n/a nM |
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| Citation |  Dinnell, K; Chicchi, GG; Dhar, MJ; Elliott, JM; Hollingworth, GJ; Kurtz, MM; Ridgill, MP; Rycroft, W; Tsao, KL; Williams, AR; Swain, CJ 2-Aryl indole NK1 receptor antagonists: optimisation of the 2-aryl ring and the indole nitrogen substituent. Bioorg Med Chem Lett11:1237-40 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50099546 |
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| n/a |
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| Name | BDBM50099546 |
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| Synonyms: | (5-Chloro-2-(4-chloro-phenyl)-3-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-3-oxo-propyl}-indol-1-yl)-acetic acid methyl ester | CHEMBL423836 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H31Cl2N3O4 |
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| Mol. Mass. | 580.502 |
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| SMILES | COC(=O)Cn1c(c(CCC(=O)N2CCN(CC2)c2ccccc2OC)c2cc(Cl)ccc12)-c1ccc(Cl)cc1 |
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| Structure | 
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