| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-enolase |
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| Ligand | BDBM50543111 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1988445 (CHEMBL4621992) |
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| IC50 | 3945±n/a nM |
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| Citation |  Yan, VC; Yang, KL; Ballato, ES; Khadka, S; Shrestha, P; Arthur, K; Georgiou, DK; Washington, M; Tran, T; Poral, AH; Pham, CD; Yan, MJ; Muller, FL Bioreducible Phosphonoamidate Pro-drug Inhibitor of Enolase: Proof of Concept Study. ACS Med Chem Lett11:1484-1489 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-enolase |
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| Name: | Alpha-enolase |
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| Synonyms: | 2-phospho-D-glycerate hydro-lyase | 4.2.1.11 | C-myc promoter-binding protein | ENO1 | ENO1L1 | ENOA_HUMAN | Enolase 1 | Enolase 1 (ENO1) | MBP-1 | MBPB1 | MPB-1 | MPB1 | NNE | Non-neural enolase | Phosphopyruvate hydratase | Plasminogen-binding protein |
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| Type: | n/a |
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| Mol. Mass.: | 47171.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06733 |
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| Residue: | 434 |
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| Sequence: | MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGK
GVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCK
AGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFRE
AMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKV
VIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDD
WGAWQKFTASAGIQVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLA
QANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSK
AKFAGRNFRNPLAK
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| BDBM50543111 |
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| n/a |
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| Name | BDBM50543111 |
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| Synonyms: | CHEMBL4633981 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H27N2O6P |
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| Mol. Mass. | 398.3905 |
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| SMILES | CC(C)(C)C(=O)OCOP(=O)(NCc1ccccc1)C1CCCN(O)C1=O |
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| Structure | 
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