| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic translation initiation factor 4E |
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| Ligand | BDBM50543774 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1989849 (CHEMBL4623584) |
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| IC50 | 1400±n/a nM |
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| Citation |  Golojuch, S; Kopcial, M; Strzelecka, D; Kasprzyk, R; Baran, N; Sikorski, PJ; Kowalska, J; Jemielity, J Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation. Bioorg Med Chem28:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic translation initiation factor 4E |
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| Name: | Eukaryotic translation initiation factor 4E |
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| Synonyms: | EIF4E | IF4E_RABIT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 25047.40 |
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| Organism: | Oryctolagus cuniculus |
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| Description: | ChEMBL_1511842 |
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| Residue: | 217 |
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| Sequence: | MATVEPETTPTPNPPPAEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
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| BDBM50543774 |
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| n/a |
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| Name | BDBM50543774 |
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| Synonyms: | CHEMBL4640855 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H20N5O7PS |
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| Mol. Mass. | 469.409 |
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| SMILES | Nc1nc([O-])c2[n+](Cc3ccccc3)cn([C@@H]3O[C@H](COP(O)(S)=O)[C@@H](O)[C@H]3O)c2n1 |r| |
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| Structure | 
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