| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacylase sirtuin-6 |
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| Ligand | BDBM50544038 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1991256 (CHEMBL4624991) |
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| IC50 | 12490±n/a nM |
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| Citation |  Sun, W; Chen, X; Huang, S; Li, W; Tian, C; Yang, S; Li, L Discovery of 5-(4-methylpiperazin-1-yl)-2-nitroaniline derivatives as a new class of SIRT6 inhibitors. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacylase sirtuin-6 |
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| Name: | NAD-dependent protein deacylase sirtuin-6 |
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| Synonyms: | NAD-dependent protein deacetylase sirtuin-6 | NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | Regulatory protein SIR2 homolog 6 | SIR2-like protein 6 | SIR2L6 | SIR6_HUMAN | SIRT6 | Sirtuin-6 (SIRT6) |
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| Type: | Protein |
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| Mol. Mass.: | 39133.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8N6T7 |
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| Residue: | 355 |
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| Sequence: | MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASG
IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV
RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGE
LRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVN
LQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPK
EESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
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| BDBM50544038 |
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| n/a |
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| Name | BDBM50544038 |
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| Synonyms: | CHEMBL249033 | US11459308, Compound 3514 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H22N4O2 |
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| Mol. Mass. | 326.3929 |
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| SMILES | CN1CCN(CC1)c1ccc(c(NCc2ccccc2)c1)[N+]([O-])=O |
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| Structure | 
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