Ki Summary

Reaction Details

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Target

Prostaglandin E2 receptor EP4 subtype

Ligand

BDBM50101861

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_158448 (CHEMBL763252)

EC50

3.6±n/a nM

Citation

Maruyama, T; Asada, M; Shiraishi, T; Sakata, K; Seki, A; Yoshida, H; Shinagawa, Y; Maruyama, T; Ohuchida, S; Nakai, H; Kondo, K; Toda, M Design and synthesis of a highly selective EP4-receptor agonist. Part 2: 5-thia and 9beta-haloPG derivatives with improved stability. Bioorg Med Chem Lett11:2033-5 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

Prostaglandin E2 receptor EP4 subtype

Name:

Prostaglandin E2 receptor EP4 subtype

Synonyms:

PE2R4_MOUSE | PGE receptor, EP4 subtype | Prostanoid EP4 receptor | Ptger4 | Ptgerep4

Type:

G-protein coupled receptor

Mol. Mass.:

56175.66

Organism:

Mus musculus (Mouse)

Description:

n/a

Residue:

513

Sequence:

MAEVGGTIPRSNRELQRCVLLTTTIMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGN
LVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYS
TFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAIYASNVLFCALPN
MGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHR
QFMRRTSLGTEQHHAAAAAAVASVACRGHAGASPALQRLSDFRRRRSFRRIAGAEIQMVI
LLIATSLVVLICSIPLVVRVFINQLYQPNVVKDISRNPDLQAIRIASVNPILDPWIYILL
RKTVLSKAIEKIKCLFCRIGGSGRDSSAQHCSESRRTSSAMSGHSRSFLARELKEISSTS
QTLLYLPDLTESSLGGRNLLPGSHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVD
EVSGSHREEPASKGNSLQVTFPSETLKLSEKCI

BDBM50101861

n/a

Name

BDBM50101861

Synonyms:

4-{(S)-2-[(R)-3-Hydroxy-2-((1R,2R)-3-hydroxy-oct-1-enyl)-5-oxo-cyclopentyl]-ethylsulfanyl}-butyric acid | CHEMBL64187

Type

Small organic molecule

Emp. Form.

C19H32O5S

Mol. Mass.

372.519

SMILES

CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(O)=O

Structure