| Reaction Details |
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 | Report a problem with these data |
| Target | Sialin |
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| Ligand | BDBM50545752 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1996365 (CHEMBL4630260) |
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| IC50 | 2400±n/a nM |
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| Citation |  Dubois, L; Pietrancosta, N; Cabaye, A; Fanget, I; Debacker, C; Gilormini, PA; Dansette, PM; Dairou, J; Biot, C; Froissart, R; Goupil-Lamy, A; Bertrand, HO; Acher, FC; McCort-Tranchepain, I; Gasnier, B; Anne, C Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin. J Med Chem63:8231-8249 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sialin |
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| Name: | Sialin |
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| Synonyms: | AST | H(+)/nitrate cotransporter | H(+)/sialic acid cotransporter | Membrane glycoprotein HP59 | S17A5_HUMAN | SLC17A5 | Sialin | Solute carrier family 17 member 5 | Vesicular H(+)/Aspartate-glutamate cotransporter |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54648.96 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119952 |
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| Residue: | 495 |
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| Sequence: | MRSPVRDLARNDGEESTDRTPLLPGAPRAEAAPVCCSARYNLAILAFFGFFIVYALRVNL
SVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYI
ITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFP
AMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFW
FLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSSQKSVPWVPILKSLPLWAIVVAHFS
YNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFST
LCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPS
YAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKG
EVQNWALNDHHGHRH
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| BDBM50545752 |
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| n/a |
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| Name | BDBM50545752 |
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| Synonyms: | CHEMBL4646356 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H23NO7S |
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| Mol. Mass. | 517.55 |
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| SMILES | OC(=O)[C@H](CSCc1cc(=O)oc2cc(O)ccc12)NC(=O)OCC1c2ccccc2-c2ccccc12 |r| |
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| Structure | 
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