| Reaction Details |
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 | Report a problem with these data |
| Target | Ephrin type-A receptor 8 |
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| Ligand | BDBM6511 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2014133 (CHEMBL4667711) |
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| Kd | 560±n/a nM |
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| Citation |  Asquith, CRM; Treiber, DK; Zuercher, WJ Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK). Bioorg Med Chem Lett29:1727-1731 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ephrin type-A receptor 8 |
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| Name: | Ephrin type-A receptor 8 |
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| Synonyms: | EEK | EPHA8 | EPHA8_HUMAN | Ephrin receptor | Ephrin type-A receptor 8 | HEK3 | KIAA1459 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 111022.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774600 |
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| Residue: | 1005 |
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| Sequence: | MAPARGRLPPALWVVTAAAAAATCVSAARGEVNLLDTSTIHGDWGWLTYPAHGWDSINEV
DESFQPIHTYQVCNVMSPNQNNWLRTSWVPRDGARRVYAEIKFTLRDCNSMPGVLGTCKE
TFNLYYLESDRDLGASTQESQFLKIDTIAADESFTGADLGVRRLKLNTEVRSVGPLSKRG
FYLAFQDIGACLAILSLRIYYKKCPAMVRNLAAFSEAVTGADSSSLVEVRGQCVRHSEER
DTPKMYCSAEGEWLVPIGKCVCSAGYEERRDACVACELGFYKSAPGDQLCARCPPHSHSA
APAAQACHCDLSYYRAALDPPSSACTRPPSAPVNLISSVNGTSVTLEWAPPLDPGGRSDI
TYNAVCRRCPWALSRCEACGSGTRFVPQQTSLVQASLLVANLLAHMNYSFWIEAVNGVSD
LSPEPRRAAVVNITTNQAAPSQVVVIRQERAGQTSVSLLWQEPEQPNGIILEYEIKYYEK
DKEMQSYSTLKAVTTRATVSGLKPGTRYVFQVRARTSAGCGRFSQAMEVETGKPRPRYDT
RTIVWICLTLITGLVVLLLLLICKKRHCGYSKAFQDSDEEKMHYQNGQAPPPVFLPLHHP
PGKLPEPQFYAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQR
DVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGS
LDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFG
LSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYW
NMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPE
SLRATATVSRCPPPAFVRSCFDLRGGSGGGGGLTVGDWLDSIRMGRYRDHFAAGGYSSLG
MVLRMNAQDVRALGITLMGHQKKILGSIQTMRAQLTSTQGPRRHL
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| BDBM6511 |
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| n/a |
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| Name | BDBM6511 |
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| Synonyms: | 4-Anilinoquinoline deriv. 8 | 6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N2O5 |
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| Mol. Mass. | 370.3991 |
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| SMILES | COc1cc(Nc2ccnc3cc(OC)c(OC)cc23)cc(OC)c1OC |
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| Structure | 
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