| Reaction Details |
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 | Report a problem with these data |
| Target | Cruzipain |
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| Ligand | BDBM50546138 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2014410 (CHEMBL4667988) |
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| IC50 | 26000±n/a nM |
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| Citation |  Pereira, GAN; da Silva, EB; Braga, SFP; Leite, PG; Martins, LC; Vieira, RP; Soh, WT; Villela, FS; Costa, FMR; Ray, D; de Andrade, SF; Brandstetter, H; Oliveira, RB; Caffrey, CR; Machado, FS; Ferreira, RS Discovery and characterization of trypanocidal cysteine protease inhibitors from the 'malaria box'. Eur J Med Chem179:765-778 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cruzipain |
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| Name: | Cruzipain |
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| Synonyms: | CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase |
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| Type: | Protein |
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| Mol. Mass.: | 49831.41 |
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| Organism: | Trypanosoma cruzi |
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| Description: | P25779 |
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| Residue: | 467 |
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| Sequence: | MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLS
VFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEV
VGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK
TDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVEL
PQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYW
IIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSY
FVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVR
SSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
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| BDBM50546138 |
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| n/a |
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| Name | BDBM50546138 |
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| Synonyms: | CHEMBL4793916 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H22BrCl3N2O |
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| Mol. Mass. | 456.632 |
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| SMILES | Cl.Cl.Clc1cc(Br)ccc1-c1ccc(CNCC2CCNCC2)o1 |
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| Structure | 
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