| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteine protease |
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| Ligand | BDBM50518231 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2014412 (CHEMBL4667990) |
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| IC50 | 30000±n/a nM |
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| Citation |  Pereira, GAN; da Silva, EB; Braga, SFP; Leite, PG; Martins, LC; Vieira, RP; Soh, WT; Villela, FS; Costa, FMR; Ray, D; de Andrade, SF; Brandstetter, H; Oliveira, RB; Caffrey, CR; Machado, FS; Ferreira, RS Discovery and characterization of trypanocidal cysteine protease inhibitors from the 'malaria box'. Eur J Med Chem179:765-778 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteine protease |
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| Name: | Cysteine protease |
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| Synonyms: | Rhodesain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48425.78 |
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| Organism: | Trypanosoma brucei rhodesiense |
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| Description: | ChEMBL_619861 |
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| Residue: | 450 |
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| Sequence: | MPRTEMVRFVRLPVVLLAMAACLASVALGSLHVEESLEMRFAAFKKKYGKVYKDAKEEAF
RFRAFEENMEQAKIQAAANPYATFGVTPFSDMTREEFRARYRNGASYFAAAQKRLRKTVN
VTTGRAPAAVDWREKGAVTPVKDQGQCGSCWAFSTIGNIEGQWQVAGNPLVSLSEQMLVS
CDTIDFGCGGGLMDNAFNWIVNSNGGNVFTEASYPYVSGNGEQPQCQMNGHEIGAAITDH
VDLPQDEDAIAAYLAENGPLAIAVDATSFMDYNGGILTSCTSEQLDHGVLLVGYNDSSNP
PYWIIKNSWSNMWGEDGYIRIEKGTNQCLMNQAVSSAVVGGPTPPPPPPPPPSATFTQDF
CEGKGCTKGCSHATFPTGECVQTTGVGSVIATCGASNLTQIIYPLSRSCSGLSVPITVPL
DKCIPILIGSVEYHCSTNPPTKAARLVPHQ
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| BDBM50518231 |
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| n/a |
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| Name | BDBM50518231 |
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| Synonyms: | CHEMBL597248 | GNF-Pf-4180 | MMV006169 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18N4 |
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| Mol. Mass. | 326.3944 |
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| SMILES | C(Nc1nc(Nc2ccccc2)nc2ccccc12)c1ccccc1 |
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| Structure | 
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