| Reaction Details |
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 | Report a problem with these data |
| Target | 5'-nucleotidase |
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| Ligand | BDBM50546324 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2015107 (CHEMBL4668685) |
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| IC50 | 0.120000±n/a nM |
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| Citation |  Lawson, KV; Kalisiak, J; Lindsey, EA; Newcomb, ET; Leleti, MR; Debien, L; Rosen, BR; Miles, DH; Sharif, EU; Jeffrey, JL; Tan, JBL; Chen, A; Zhao, S; Xu, G; Fu, L; Jin, L; Park, TW; Berry, W; Moschütz, S; Scaletti, E; Sträter, N; Walker, NP; Young, SW; Walters, MJ; Schindler, U; Powers, JP Discovery of AB680: A Potent and Selective Inhibitor of CD73. J Med Chem63:11448-11468 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5'-nucleotidase |
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| Name: | 5'-nucleotidase |
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| Synonyms: | 5'-NT | 5'-nucleotidase (CD73) | 5NTD_HUMAN | CD_antigen=CD73 | Ecto-5'-nucleotidase | Ecto-5-nucleotidase (e5'NT) | NT5 | NT5E | NTE |
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| Type: | Enzyme |
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| Mol. Mass.: | 63371.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21589 |
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| Residue: | 574 |
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| Sequence: | MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
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| BDBM50546324 |
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| n/a |
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| Name | BDBM50546324 |
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| Synonyms: | CHEMBL4753354 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H26ClN5O9P2 |
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| Mol. Mass. | 541.817 |
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| SMILES | CN(C1CCCC1)c1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| |
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| Structure | 
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