Reaction Details |
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Target | 5'-nucleotidase |
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Ligand | BDBM18136 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2015157 (CHEMBL4668735) |
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IC50 | 187±n/a nM |
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Citation | Lawson, KV; Kalisiak, J; Lindsey, EA; Newcomb, ET; Leleti, MR; Debien, L; Rosen, BR; Miles, DH; Sharif, EU; Jeffrey, JL; Tan, JBL; Chen, A; Zhao, S; Xu, G; Fu, L; Jin, L; Park, TW; Berry, W; Moschütz, S; Scaletti, E; Sträter, N; Walker, NP; Young, SW; Walters, MJ; Schindler, U; Powers, JP Discovery of AB680: A Potent and Selective Inhibitor of CD73. J Med Chem63:11448-11468 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5'-nucleotidase |
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Name: | 5'-nucleotidase |
Synonyms: | 5'-NT | 5'-nucleotidase (CD73) | 5NTD_HUMAN | CD_antigen=CD73 | Ecto-5'-nucleotidase | Ecto-5-nucleotidase (e5'NT) | NT5 | NT5E | NTE |
Type: | Enzyme |
Mol. Mass.: | 63371.54 |
Organism: | Homo sapiens (Human) |
Description: | P21589 |
Residue: | 574 |
Sequence: | MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
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BDBM18136 |
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n/a |
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Name | BDBM18136 |
Synonyms: | ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)methyl]phosphonic acid | alpha, beta-methyleneadenosine 5 -diphosphate | cid_92199 |
Type | Nucleoside or nucleotide |
Emp. Form. | C11H17N5O9P2 |
Mol. Mass. | 425.2283 |
SMILES | Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| |
Structure |
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