Reaction Details |
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Target | Phospholipid hydroperoxide glutathione peroxidase |
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Ligand | BDBM50547193 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2017294 (CHEMBL4670872) |
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EC50 | 44±n/a nM |
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Citation | Eaton, JK; Furst, L; Cai, LL; Viswanathan, VS; Schreiber, SL Structure-activity relationships of GPX4 inhibitor warheads. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Phospholipid hydroperoxide glutathione peroxidase |
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Name: | Phospholipid hydroperoxide glutathione peroxidase |
Synonyms: | 1.11.1.12 | GPX4 | GPX4_HUMAN | GPx-4 | GSHPx-4 | Glutathione peroxidase 4 | PHGPx |
Type: | PROTEIN |
Mol. Mass.: | 22031.99 |
Organism: | Homo sapiens |
Description: | ChEMBL_117999 |
Residue: | 196 |
Sequence: | MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR
GFVCIVTNVASQGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFAA
GYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYG
PMEEPLVIEKDLPHYF
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BDBM50547193 |
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n/a |
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Name | BDBM50547193 |
Synonyms: | CHEMBL1951048 |
Type | Small organic molecule |
Emp. Form. | C22H20Cl2N4O4 |
Mol. Mass. | 475.325 |
SMILES | Cc1onc(C(=O)N2CCN(CC2)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1[N+]([O-])=O |
Structure |
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