| Reaction Details |
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 | Report a problem with these data |
| Target | Phospholipid hydroperoxide glutathione peroxidase |
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| Ligand | BDBM50547231 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2017295 (CHEMBL4670873) |
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| EC50 | >33000±n/a nM |
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| Citation |  Eaton, JK; Furst, L; Cai, LL; Viswanathan, VS; Schreiber, SL Structure-activity relationships of GPX4 inhibitor warheads. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phospholipid hydroperoxide glutathione peroxidase |
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| Name: | Phospholipid hydroperoxide glutathione peroxidase |
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| Synonyms: | 1.11.1.12 | GPX4 | GPX4_HUMAN | GPx-4 | GSHPx-4 | Glutathione peroxidase 4 | PHGPx |
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| Type: | PROTEIN |
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| Mol. Mass.: | 22031.99 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117999 |
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| Residue: | 196 |
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| Sequence: | MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR
GFVCIVTNVASQGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFAA
GYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYG
PMEEPLVIEKDLPHYF
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| BDBM50547231 |
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| n/a |
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| Name | BDBM50547231 |
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| Synonyms: | CHEMBL4761247 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H25N3O4 |
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| Mol. Mass. | 359.4195 |
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| SMILES | CCCCCCCN(C(=O)c1noc(C)c1[N+]([O-])=O)c1cccc(C)c1 |
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| Structure | 
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