| Reaction Details |
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 | Report a problem with these data |
| Target | Thioredoxin reductase 1, cytoplasmic |
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| Ligand | BDBM50547498 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2018404 (CHEMBL4671982) |
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| IC50 | 200±n/a nM |
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| Citation |  Zhu, P; Qian, J; Xu, Z; Meng, C; Liu, J; Shan, W; Zhu, W; Wang, Y; Yang, Y; Zhang, W; Zhang, Y; Ling, Y Piperlonguminine and Piperine Analogues as TrxR Inhibitors that Promote ROS and Autophagy and Regulate p38 and Akt/mTOR Signaling. J Nat Prod83:3041-3049 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thioredoxin reductase 1, cytoplasmic |
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| Name: | Thioredoxin reductase 1, cytoplasmic |
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| Synonyms: | GRIM-12 | GRIM12 | Gene associated with retinoid-IFN-induced mortality 12 protein | KDRF | KM-102-derived reductase-like factor | TR | TRXR1_HUMAN | TXNRD1 | Thioredoxin reductase 1 | Thioredoxin reductase 1 (TrxR) | Thioredoxin reductase TR1 |
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| Type: | Protein |
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| Mol. Mass.: | 70761.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16881 |
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| Residue: | 648 |
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| Sequence: | MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQ
AYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDL
PVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKE
AAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKV
EETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEK
IYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLA
GIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIY
AIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKA
VEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQ
GFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCG
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| BDBM50547498 |
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| n/a |
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| Name | BDBM50547498 |
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| Synonyms: | CHEMBL4755909 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19NO |
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| Mol. Mass. | 253.3389 |
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| SMILES | CN(C)c1ccc(\C=C\C=C2/CCC=CC2=O)cc1 |c:13| |
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| Structure | 
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