| Reaction Details |
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 | Report a problem with these data |
| Target | Aspartyl/asparaginyl beta-hydroxylase |
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| Ligand | BDBM50547621 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2018812 (CHEMBL4672390) |
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| IC50 | 1990±n/a nM |
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| Citation |  Brewitz, L; Tumber, A; Zhang, X; Schofield, CJ Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-?-hydroxylase. Bioorg Med Chem28:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aspartyl/asparaginyl beta-hydroxylase |
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| Name: | Aspartyl/asparaginyl beta-hydroxylase |
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| Synonyms: | 1.14.11.16 | ASP beta-hydroxylase | ASPH | ASPH_HUMAN | Aspartate beta-hydroxylase | Aspartyl/asparaginyl beta-hydroxylase | BAH | Peptide-aspartate beta-dioxygenase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 85823.27 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_120098 |
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| Residue: | 758 |
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| Sequence: | MAQRKNAKSSGNSSSSGSGSGSTSAGSSSPGARRETKHGGHKNGRKGGLSGTSFFTWFMV
IALLGVWTSVAVVWFDLVDYEEVLGKLGIYDADGDGDFDVDDAKVLLGLKERSTSEPAVP
PEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVHAEHVEGEDLQQEDGPTGEPQ
QEDDEFLMATDVDDRFETLEPEVSHEETEHSYHVEETVSQDCNQDMEEMMSEQENPDSSE
PVVEDERLHHDTDDVTYQVYEEQAVYEPLENEGIEITEVTAPPEDNPVEDSQVIVEEVSI
FPVEEQQEVPPETNRKTDDPEQKAKVKKKKPKLLNKFDKTIKAELDAAEKLRKRGKIEEA
VNAFKELVRKYPQSPRARYGKAQCEDDLAEKRRSNEVLRGAIETYQEVASLPDVPADLLK
LSLKRRSDRQQFLGHMRGSLLTLQRLVQLFPNDTSLKNDLGVGYLLIGDNDNAKKVYEEV
LSVTPNDGFAKVHYGFILKAQNKIAESIPYLKEGIESGDPGTDDGRFYFHLGDAMQRVGN
KEAYKWYELGHKRGHFASVWQRSLYNVNGLKAQPWWTPKETGYTELVKSLERNWKLIRDE
GLAVMDKAKGLFLPEDENLREKGDWSQFTLWQQGRRNENACKGAPKTCTLLEKFPETTGC
RRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKIRCANETKTWEEGKVLIFD
DSFEHEVWQDASSFRLIFIVDVWHPELTPQQRRSLPAI
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| BDBM50547621 |
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| n/a |
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| Name | BDBM50547621 |
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| Synonyms: | Blenamax | Bleo-kyowa | Bleocin | Bleomycin | Bleomycin hexal | Bleomycin hydrochloride | Bleomycins | CHEBI:3139 | NSC-125066 |
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| Type | Small organic molecule |
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| Emp. Form. | C55H84N17O21S3 |
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| Mol. Mass. | 1415.551 |
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| SMILES | [H][C@](NC(=O)c1nc(nc(N)c1C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)([C@@H](O[C@@H]1O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](OC(N)=O)[C@@H]1O)c1c[nH]cn1)C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCCc1nc(cs1)-c1nc(cs1)C(=O)NCCC[S+](C)C |r| |
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| Structure | 
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