Reaction Details | |||
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Target | Gamma-aminobutyric acid receptor subunit beta-3 | ||
Ligand | BDBM50106148 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_68417 | ||
IC50 | 28±n/a nM | ||
Citation | Sirisoma, NS; Ratra, GS; Tomizawa, M; Casida, JE Fipronil-based photoaffinity probe for Drosophila and human beta 3 GABA receptors. Bioorg Med Chem Lett11:2979-81 (2001) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Gamma-aminobutyric acid receptor subunit beta-3 | |||
Name: | Gamma-aminobutyric acid receptor subunit beta-3 | ||
Synonyms: | GABA A receptor alpha-4/beta-3/gamma-2 | GABA receptor beta-3 subunit | GABA-A receptor | GABRB3 | GBRB3_HUMAN | agonist GABA site | ||
Type: | PROTEIN | ||
Mol. Mass.: | 54130.51 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_448071 | ||
Residue: | 473 | ||
Sequence: |
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BDBM50106148 | |||
n/a | |||
Name | BDBM50106148 | ||
Synonyms: | 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile | CHEMBL101326 | Fipronil | ||
Type | Small organic molecule | ||
Emp. Form. | C12H4Cl2F6N4OS | ||
Mol. Mass. | 437.148 | ||
SMILES | Nc1c(c(nn1-c1c(Cl)cc(cc1Cl)C(F)(F)F)C#N)S(=O)C(F)(F)F |(7.75,-3.07,;6.27,-2.6,;5.81,-1.15,;4.26,-1.15,;3.77,-2.62,;5.03,-3.52,;5.06,-5.06,;6.39,-5.83,;7.72,-5.05,;6.39,-7.39,;5.06,-8.16,;3.73,-7.39,;3.73,-5.83,;2.39,-5.07,;5.06,-9.7,;3.82,-10.73,;6.32,-10.73,;5.06,-11.11,;3.35,.09,;2.43,1.35,;6.69,.11,;6.06,1.52,;8.24,-.05,;9.31,-.92,;8.92,1.36,;9.62,.13,)| | ||
Structure |