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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Gamma-aminobutyric acid receptor subunit beta-3 | ||
| Ligand | BDBM50106148 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_68417 (CHEMBL680333) | ||
| IC50 | 28±n/a nM | ||
| Citation |  Sirisoma, NS; Ratra, GS; Tomizawa, M; Casida, JE Fipronil-based photoaffinity probe for Drosophila and human beta 3 GABA receptors. Bioorg Med Chem Lett11:2979-81 (2001) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Gamma-aminobutyric acid receptor subunit beta-3 | |||
| Name: | Gamma-aminobutyric acid receptor subunit beta-3 | ||
| Synonyms: | GABA A receptor alpha-4/beta-3/gamma-2 | GABA receptor beta-3 subunit | GABA-A receptor | GABRB3 | GBRB3_HUMAN | agonist GABA site | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 54130.51 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_448071 | ||
| Residue: | 473 | ||
| Sequence: |
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| BDBM50106148 | |||
| n/a | |||
| Name | BDBM50106148 | ||
| Synonyms: | 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile | CHEMBL101326 | Fipronil | ||
| Type | Small organic molecule | ||
| Emp. Form. | C12H4Cl2F6N4OS | ||
| Mol. Mass. | 437.148 | ||
| SMILES | Nc1c(c(nn1-c1c(Cl)cc(cc1Cl)C(F)(F)F)C#N)S(=O)C(F)(F)F |(7.75,-3.07,;6.27,-2.6,;5.81,-1.15,;4.26,-1.15,;3.77,-2.62,;5.03,-3.52,;5.06,-5.06,;6.39,-5.83,;7.72,-5.05,;6.39,-7.39,;5.06,-8.16,;3.73,-7.39,;3.73,-5.83,;2.39,-5.07,;5.06,-9.7,;3.82,-10.73,;6.32,-10.73,;5.06,-11.11,;3.35,.09,;2.43,1.35,;6.69,.11,;6.06,1.52,;8.24,-.05,;9.31,-.92,;8.92,1.36,;9.62,.13,)| | ||
| Structure | 
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