Reaction Details |
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Target | Potassium voltage-gated channel subfamily E/KQT member 1 |
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Ligand | BDBM50106237 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_158552 (CHEMBL768695) |
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IC50 | 400±n/a nM |
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Citation | Gerlach, U; Brendel, J; Lang, HJ; Paulus, EF; Weidmann, K; Brüggemann, A; Busch, AE; Suessbrich, H; Bleich, M; Greger, R Synthesis and activity of novel and selective I(Ks)-channel blockers. J Med Chem44:3831-7 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Potassium voltage-gated channel subfamily E/KQT member 1 |
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Name: | Potassium voltage-gated channel subfamily E/KQT member 1 |
Synonyms: | Voltage-gated potassium channel beta subunit Mink/subunit Kv7.1 | Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 158552 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Potassium voltage-gated channel subfamily E member 1 |
Synonyms: | Delayed rectifier potassium channel subunit IsK | IKs producing slow voltage-gated potassium channel subunit beta Mink | KCNE1 | KCNE1_HUMAN | KCNQ1(Kv7.1)/KCNE1(MinK) | Minimal potassium channel | Voltage-gated potassium channel beta subunit Mink | Voltage-gated potassium channel, IKs |
Type: | PROTEIN |
Mol. Mass.: | 14676.11 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1456351 |
Residue: | 129 |
Sequence: | MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLG
IMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNT
HLPETKPSP
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Component 2 |
Name: | Potassium voltage-gated channel subfamily KQT member 1 |
Synonyms: | KCNA8 | KCNA9 | KCNQ (Kv7) potassium channel | KCNQ1 | KCNQ1_HUMAN | KVLQT1 | Voltage-gated potassium channel subunit Kv7.1 | Voltage-gated potassium channel subunit Kv7.1/Misshapen-like kinase 1 |
Type: | PROTEIN |
Mol. Mass.: | 74739.00 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1454245 |
Residue: | 676 |
Sequence: | MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPG
PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGW
KCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGC
RSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH
VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYA
DALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQR
QKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKK
KKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFM
RTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRD
VIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVT
QLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLP
TYEQLTVPRRGPDEGS
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BDBM50106237 |
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n/a |
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Name | BDBM50106237 |
Synonyms: | (3S,4R)-Ethanesulfonic acid (6-benzyloxy-3-hydroxy-2,2-dimethyl-chroman-4-yl)-methyl-amide | CHEMBL127885 |
Type | Small organic molecule |
Emp. Form. | C21H27NO5S |
Mol. Mass. | 405.508 |
SMILES | CCS(=O)(=O)N(C)[C@H]1[C@H](O)C(C)(C)Oc2ccc(OCc3ccccc3)cc12 |
Structure |
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