| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM50546856 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2016819 (CHEMBL4670397) |
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| Ki | 0.025119±n/a nM |
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| Citation |  Sniecikowska, J; Gluch-Lutwin, M; Bucki, A; Wi?ckowska, A; Siwek, A; Jastrzebska-Wiesek, M; Partyka, A; Wilczy?ska, D; Pytka, K; Latacz, G; Przejczowska-Pomierny, K; Wyska, E; Weso?owska, A; Paw?owski, M; Newman-Tancredi, A; Kolaczkowski, M Discovery of Novel pERK1/2- or ?-Arrestin-Preferring 5-HT J Med Chem63:10946-10971 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A |
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| Type: | n/a |
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| Mol. Mass.: | 46122.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 422 |
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| Sequence: | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ
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| BDBM50546856 |
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| n/a |
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| Name | BDBM50546856 |
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| Synonyms: | CHEMBL4759759 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22Cl3FN2O2 |
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| Mol. Mass. | 459.769 |
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| SMILES | FC1(CNCCOc2cccc(Cl)c2)CCN(CC1)C(=O)c1ccc(Cl)c(Cl)c1 |
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| Structure | 
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