Reaction Details |
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Target | Endothelin-1 receptor |
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Ligand | BDBM50051007 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_65665 (CHEMBL677092) |
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IC50 | 0.08±n/a nM |
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Citation | Jae, HS; Winn, M; von Geldern, TW; Sorensen, BK; Chiou, WJ; Nguyen, B; Marsh, KC; Opgenorth, TJ Pyrrolidine-3-carboxylic acids as endothelin antagonists. 5. Highly selective, potent, and orally active ET(A) antagonists. J Med Chem44:3978-84 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin-1 receptor |
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Name: | Endothelin-1 receptor |
Synonyms: | EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 48256.91 |
Organism: | RAT |
Description: | ENDOTHELIN A EDNRA RAT::P26684 |
Residue: | 426 |
Sequence: | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
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BDBM50051007 |
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n/a |
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Name | BDBM50051007 |
Synonyms: | (2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid | 4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid | A-127722 | CHEMBL9194 |
Type | Small organic molecule |
Emp. Form. | C29H38N2O6 |
Mol. Mass. | 510.6218 |
SMILES | CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1ccc2OCOc2c1 |
Structure |
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