| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholinesterase |
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| Ligand | BDBM50106448 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_29414 (CHEMBL875241) |
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| IC50 | 30000±n/a nM |
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| Citation |  Andreani, A; Cavalli, A; Granaiola, M; Guardigli, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Recanatini, M; Roda, A Synthesis and screening for antiacetylcholinesterase activity of (1-benzyl-4-oxopiperidin-3-ylidene)methylindoles and -pyrroles related to donepezil. J Med Chem44:4011-4 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholinesterase |
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| Name: | Acetylcholinesterase |
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| Synonyms: | ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE) |
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| Type: | Enzyme |
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| Mol. Mass.: | 67792.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22303 |
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| Residue: | 614 |
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| Sequence: | MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
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| BDBM50106448 |
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| n/a |
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| Name | BDBM50106448 |
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| Synonyms: | 4-(1-Benzyl-4-oxo-piperidin-3-ylidenemethyl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde | CHEMBL130738 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N2O2 |
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| Mol. Mass. | 322.4009 |
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| SMILES | Cc1[nH]c(C)c(C=C2CN(Cc3ccccc3)CCC2=O)c1C=O |w:6.5| |
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| Structure | 
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