| Reaction Details |
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 | Report a problem with these data |
| Target | Kelch-like ECH-associated protein 1 |
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| Ligand | BDBM50109368 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2017163 (CHEMBL4670741) |
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| IC50 | 14±n/a nM |
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| Citation |  Zhou, HS; Hu, LB; Zhang, H; Shan, WX; Wang, Y; Li, X; Liu, T; Zhao, J; You, QD; Jiang, ZY Design, Synthesis, and Structure-Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors. J Med Chem63:11149-11168 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kelch-like ECH-associated protein 1 |
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| Name: | Kelch-like ECH-associated protein 1 |
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| Synonyms: | Cytosolic inhibitor of Nrf2 | INRF2 | KEAP1 | KEAP1/Cullin-3/Microtubule-associated protein tau | KEAP1_HUMAN | KIAA0132 | KLHL19 | Kelch-like protein 19 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69664.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107924 |
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| Residue: | 624 |
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| Sequence: | MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
RSGVGVAVTMEPCRKQIDQQNCTC
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| BDBM50109368 |
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| n/a |
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| Name | BDBM50109368 |
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| Synonyms: | CHEMBL3601212 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H28N4O10S2 |
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| Mol. Mass. | 668.694 |
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| SMILES | CC(=O)Nc1ccc(cc1)S(=O)(=O)N(CC(O)=O)c1ccc(N(CC(O)=O)S(=O)(=O)c2ccc(NC(C)=O)cc2)c2ccccc12 |
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| Structure | 
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