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TargetTranscriptional enhancer factor TEF-3
LigandBDBM85507
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2017235 (CHEMBL4670813)
IC50 41900±n/a nM
Citation Karatas, H; Akbarzadeh, M; Adihou, H; Hahne, G; Pobbati, AV; Yihui Ng, E; Guéret, SM; Sievers, S; Pahl, A; Metz, M; Zinken, S; Dötsch, L; Nowak, C; Thavam, S; Friese, A; Kang, C; Hong, W; Waldmann, H Discovery of Covalent Inhibitors Targeting the Transcriptional Enhanced Associate Domain Central Pocket. J Med Chem63:11972-11989 (2020) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Transcriptional enhancer factor TEF-3
Name:Transcriptional enhancer factor TEF-3
Synonyms:RTEF1 | TCF13L1 | TEA domain family member 4 | TEAD-4 | TEAD4 | TEAD4_HUMAN | TEF3 | Transcription factor 13-like 1 | Transcription factor RTEF-1 | Transcriptional enhancer factor TEF-3
Type:PROTEIN
Mol. Mass.:48333.01
Organism:Homo sapiens
Description:ChEMBL_118073
Residue:434
Sequence:
MEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPP
CGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQ
AAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPF
SQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPD
TYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWA
DLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYR
IHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSAS
EHGAQHHIYRLVKE
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  Blast E-value cutoff:
BDBM85507
n/a
NameBDBM85507
Synonyms:CAS_4394-00-7 | NSC_4488 | Niflumic acid | Niflumic acid (Hit 16) | US10278929, Niflumic acid | US11337935, Compound Niflumic-acid | US20240002326, Compound Niflumic acid
TypeSmall organic molecule
Emp. Form.C13H9F3N2O2
Mol. Mass.282.218
SMILESOC(=O)c1cccnc1Nc1cccc(c1)C(F)(F)F
Structure
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