| Reaction Details |
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 | Report a problem with these data |
| Target | Sterol O-acyltransferase 1 |
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| Ligand | BDBM50002953 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_28947 (CHEMBL636942) |
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| IC50 | >300000±n/a nM |
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| Citation |  Giovannoni, MP; Piaz, VD; Kwon, BM; Kim, MK; Kim, YK; Toma, L; Barlocco, D; Bernini, F; Canavesi, M 5,6-Diphenylpyridazine derivatives as acyl-CoA:cholesterol acyltransferase inhibitors. J Med Chem44:4292-5 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sterol O-acyltransferase 1 |
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| Name: | Sterol O-acyltransferase 1 |
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| Synonyms: | ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64165.56 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_28796 |
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| Residue: | 545 |
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| Sequence: | MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLF
LKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISR
RSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVI
WTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLA
YTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPT
LIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLC
VFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVH
DWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMA
FNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWT
CRYVF
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|
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| BDBM50002953 |
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| n/a |
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| Name | BDBM50002953 |
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| Synonyms: | 8-(5,6-Diphenyl-pyridazin-3-ylsulfanyl)-octanoic acid | CHEMBL117709 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N2O2S |
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| Mol. Mass. | 406.54 |
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| SMILES | OC(=O)CCCCCCCSc1cc(-c2ccccc2)c(nn1)-c1ccccc1 |
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| Structure | 
|
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