| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 4 |
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| Ligand | BDBM50547950 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2019402 (CHEMBL4672980) |
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| IC50 | 11±n/a nM |
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| Citation |  Gummadi, VR; Boruah, A; Ainan, BR; Vare, BR; Manda, S; Gondle, HP; Kumar, SN; Mukherjee, S; Gore, ST; Krishnamurthy, NR; Marappan, S; Nayak, SS; Nellore, K; Balasubramanian, WR; Bhumireddy, A; Giri, S; Gopinath, S; Samiulla, DS; Daginakatte, G; Basavaraju, A; Chelur, S; Eswarappa, R; Belliappa, C; Subramanya, HS; Booher, RN; Ramachandra, M; Samajdar, S Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies. ACS Med Chem Lett11:2374-2381 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 receptor-associated kinase 4 |
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| Name: | Interleukin-1 receptor-associated kinase 4 |
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| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
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| Type: | Protein |
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| Mol. Mass.: | 51519.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NWZ3 |
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| Residue: | 460 |
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| Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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| BDBM50547950 |
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| n/a |
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| Name | BDBM50547950 |
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| Synonyms: | CHEMBL4748475 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28N8O3 |
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| Mol. Mass. | 488.5416 |
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| SMILES | Cn1cc(cn1)-c1cccc(n1)C(=O)Nc1cc2oc(nc2nc1N1CCCCC1)N1CCOCC1 |
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| Structure | 
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