| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase kinase 1 |
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| Ligand | BDBM50548191 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2020259 (CHEMBL4674072) |
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| IC50 | 8.6±n/a nM |
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| Citation |  May-Dracka, TL; Arduini, R; Bertolotti-Ciarlet, A; Bhisetti, G; Brickelmaier, M; Cahir-McFarland, E; Enyedy, I; Fontenot, JD; Hesson, T; Little, K; Lyssikatos, J; Marcotte, D; McKee, T; Murugan, P; Patterson, T; Peng, H; Rushe, M; Silvian, L; Spilker, K; Wu, P; Xin, Z; Burkly, LC Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKC? phosphorylation: Potential therapy to modulate T cell dependent immunity. Bioorg Med Chem Lett28:1964-1971 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase kinase 1 |
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| Name: | Mitogen-activated protein kinase kinase kinase kinase 1 |
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| Synonyms: | HPK1 | M4K1_HUMAN | MAP4K1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 91316.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_586597 |
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| Residue: | 833 |
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| Sequence: | MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
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| BDBM50548191 |
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| n/a |
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| Name | BDBM50548191 |
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| Synonyms: | CHEMBL4793665 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25N5OS |
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| Mol. Mass. | 395.521 |
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| SMILES | CCN1CCC(CC1)c1ncc(s1)-c1cnc(N)c(OCc2ccncc2)c1 |
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| Structure | 
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