| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydrofolate reductase |
|---|
| Ligand | BDBM50078468 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_55100 (CHEMBL665360) |
|---|
| IC50 | 0.82±n/a nM |
|---|
| Citation |  Debnath, AK Pharmacophore mapping of a series of 2,4-diamino-5-deazapteridine inhibitors of Mycobacterium avium complex dihydrofolate reductase. J Med Chem45:41-53 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydrofolate reductase |
|---|
| Name: | Dihydrofolate reductase |
|---|
| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 21453.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant human DHFR. |
|---|
| Residue: | 187 |
|---|
| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
|
|
|
|---|
| BDBM50078468 |
|---|
| n/a |
|---|
| Name | BDBM50078468 |
|---|
| Synonyms: | 6-[(3-Chloro-phenylamino)-methyl]-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine | CHEMBL80066 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H15ClN6 |
|---|
| Mol. Mass. | 314.773 |
|---|
| SMILES | Cc1c(CNc2cccc(Cl)c2)cnc2nc(N)nc(N)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
