Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50108179 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_54943 (CHEMBL669014) |
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IC50 | 12000±n/a nM |
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Citation | Rosowsky, A; Forsch, RA; Queener, SF Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selectivity relative to piritrexim. J Med Chem45:233-41 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21638.84 |
Organism: | Rattus norvegicus (rat) |
Description: | n/a |
Residue: | 187 |
Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKF
EVYEKKD
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BDBM50108179 |
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n/a |
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Name | BDBM50108179 |
Synonyms: | 9-[3-(2,4-Diamino-pyrimidin-5-ylmethyl)-4-methoxy-phenoxy]-nonanoic acid | CHEMBL38332 |
Type | Small organic molecule |
Emp. Form. | C21H30N4O4 |
Mol. Mass. | 402.4873 |
SMILES | COc1ccc(OCCCCCCCCC(O)=O)cc1Cc1cnc(N)nc1N |
Structure |
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