Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50108178 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_55098 (CHEMBL665358) |
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IC50 | 390±n/a nM |
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Citation | Rosowsky, A; Forsch, RA; Queener, SF Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selectivity relative to piritrexim. J Med Chem45:233-41 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 19884.75 |
Organism: | Mycobacterium avium |
Description: | Recombinant Mycobacterium avium DHFR expressed in E. coli. |
Residue: | 181 |
Sequence: | MTRAEVGLVWAQSTSGVIGRGGDIPWSVPEDLTRFKEVTMGHTVIMGRRTWESLPAKVRP
LPGRRNVVVSRRPDFVAEGARVAGSLEAALAYAGSDPAPWVIGGAQIYLLALPHATRCEV
TEIEIDLRRDDDDALAPALDDSWVGETGEWLASRSGLRYRFHSYRRDPRSSVRGCSPSRP
S
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BDBM50108178 |
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n/a |
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Name | BDBM50108178 |
Synonyms: | 5-(5-Hexyloxy-2-methoxy-benzyl)-pyrimidine-2,4-diamine | CHEMBL284851 |
Type | Small organic molecule |
Emp. Form. | C18H26N4O2 |
Mol. Mass. | 330.4246 |
SMILES | CCCCCCOc1ccc(OC)c(Cc2cnc(N)nc2N)c1 |
Structure |
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