Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein phosphatase non-receptor type 11 | ||
| Ligand | BDBM497144 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2025657 (CHEMBL4679470) | ||
| IC50 | 0.800000±n/a nM | ||
| Citation |  Sabnis, RW Novel Pyrimidinones as SHP2 Antagonists for Treating Cancer. ACS Med Chem Lett12:3-4 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein phosphatase non-receptor type 11 | |||
| Name: | Tyrosine-protein phosphatase non-receptor type 11 | ||
| Synonyms: | 3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2) | ||
| Type: | Protein phosphatase | ||
| Mol. Mass.: | 68443.59 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06124 | ||
| Residue: | 593 | ||
| Sequence: |
| ||
| BDBM497144 | |||
| n/a | |||
| Name | BDBM497144 | ||
| Synonyms: | US11001561, Compound 119a | US11702392, Compound 119a | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H24Cl2N4O | ||
| Mol. Mass. | 455.38 | ||
| SMILES | Cc1nc(cc(=O)n1-c1cccc(Cl)c1Cl)N1CCC2(Cc3ccccc3[C@H]2N)CC1 |wD:27.31,(-2.2,-1.1,;-1.43,-2.44,;.11,-2.44,;.88,-3.77,;.11,-5.1,;-1.43,-5.1,;-2.2,-6.44,;-2.2,-3.77,;-3.74,-3.77,;-4.51,-2.44,;-6.05,-2.44,;-6.82,-3.77,;-6.05,-5.1,;-6.82,-6.44,;-4.51,-5.1,;-3.74,-6.44,;2.42,-3.77,;3.19,-5.1,;4.73,-5.1,;5.5,-3.77,;6.4,-5.02,;7.87,-4.54,;9.2,-5.31,;10.53,-4.54,;10.53,-3,;9.2,-2.23,;7.87,-3,;6.4,-2.53,;5.92,-1.06,;4.73,-2.44,;3.19,-2.44,)| | ||
| Structure | 
| ||