| Reaction Details |
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 | Report a problem with these data |
| Target | Protein cereblon |
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| Ligand | BDBM14361 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2025843 (CHEMBL4679656) |
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| IC50 | 202000±n/a nM |
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| Citation |  Maiwald, S; Heim, C; Hernandez Alvarez, B; Hartmann, MD Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay. ACS Med Chem Lett12:74-81 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein cereblon |
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| Name: | Protein cereblon |
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| Synonyms: | CRBN | CRBN_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50537.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_116917 |
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| Residue: | 442 |
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| Sequence: | MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL
GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW
PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLK
IGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETL
TVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS
ALLPTIPDTEDEISPDKVILCL
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| BDBM14361 |
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| n/a |
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| Name | BDBM14361 |
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| Synonyms: | (R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrolidin-2-one | 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one | Adeo | CHEMBL63 | Rolipram |
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| Type | Small organic molecule |
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| Emp. Form. | C16H21NO3 |
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| Mol. Mass. | 275.3428 |
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| SMILES | COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 |
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| Structure | 
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