| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK1 |
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| Ligand | BDBM50549846 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2025904 (CHEMBL4679717) |
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| Ki | >4000±n/a nM |
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| Citation |  Bandarage, UK; Aronov, AM; Cao, J; Come, JH; Cottrell, KM; Davies, RJ; Giroux, S; Jacobs, M; Mahajan, S; Messersmith, D; Moody, CS; Swett, R; Xu, J Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3K? Inhibitors. ACS Med Chem Lett12:129-135 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PLK1 |
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| Name: | Serine/threonine-protein kinase PLK1 |
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| Synonyms: | PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 68277.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P53350 |
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| Residue: | 603 |
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| Sequence: | MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
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| BDBM50549846 |
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| n/a |
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| Name | BDBM50549846 |
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| Synonyms: | CHEMBL4764646 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N5O2S |
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| Mol. Mass. | 395.478 |
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| SMILES | Cc1nc(NC(=O)NCCOCC2CC2)sc1C#Cc1ccc2cncn2c1 |
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| Structure | 
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