Reaction Details |
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Target | Cytochrome P450 1B1 |
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Ligand | BDBM50014323 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2029699 (CHEMBL4683857) |
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IC50 | 4.1±n/a nM |
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Citation | Zhou, L; Chen, W; Cao, C; Shi, Y; Ye, W; Hu, J; Wang, L; Zhou, W Design and synthesis of ?-naphthoflavone chimera derivatives able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation. Eur J Med Chem189:0 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 1B1 |
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Name: | Cytochrome P450 1B1 |
Synonyms: | CP1B1_HUMAN | CYP1B1 | CYPIB1 | Cytochrome P450 1B1 (CYP1B1) |
Type: | PROTEIN |
Mol. Mass.: | 60861.81 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1474523 |
Residue: | 543 |
Sequence: | MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI
GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF
ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL
LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL
VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSA
EKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAEL
DQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVV
FVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL
FLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKE
TCQ
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BDBM50014323 |
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n/a |
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Name | BDBM50014323 |
Synonyms: | 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE | 2-Phenyl-benzo[h]chromen-4-one | 7,8-Benzoflavone | CHEMBL283196 | alpha-naphthoflavone |
Type | Small organic molecule |
Emp. Form. | C19H12O2 |
Mol. Mass. | 272.2974 |
SMILES | O=c1cc(oc2c3ccccc3ccc12)-c1ccccc1 |
Structure |
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