| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50110639 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_205886 |
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| Ki | 0.700000±n/a nM |
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| Citation |  Reichard, GA; Spitler, J; Aslanian, R; Mutahi, M; Shih, NY; Lin, L; Ting, PC; Anthes, JC; Piwinski, JJ Structure-activity relationships of oxime neurokinin antagonists: oxime modifications. Bioorg Med Chem Lett12:833-6 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50110639 |
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| n/a |
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| Name | BDBM50110639 |
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| Synonyms: | CHEMBL355429 | [1-{[(3,5-Dichloro-benzoyl)-methyl-amino]-methyl}-2-(3,4-dichloro-phenyl)-4-(2-oxo-[1,4']bipiperidinyl-1'-yl)-but-(Z)-ylideneaminooxy]-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C31H36Cl4N4O5 |
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| Mol. Mass. | 686.453 |
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| SMILES | CN(C\C(=N/OCC(O)=O)C(CCN1CCC(CC1)N1CCCCC1=O)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 |
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| Structure | 
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