| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
|---|
| Ligand | BDBM50551309 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2031142 (CHEMBL4685300) |
|---|
| Ki | 3.0±n/a nM |
|---|
| Citation |  Sz?cs, E; Marton, J; Szabó, Z; Hosztafi, S; Kékesi, G; Tuboly, G; Bánki, L; Horváth, G; Szabó, PT; Tömböly, C; Varga, ZK; Benyhe, S; Ötvös, F Synthesis, biochemical, pharmacological characterization and in silico profile modelling of highly potent opioid orvinol and thevinol derivatives. Eur J Med Chem191:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kappa-type opioid receptor |
|---|
| Name: | Kappa-type opioid receptor |
|---|
| Synonyms: | Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 42744.99 |
|---|
| Organism: | Cavia porcellus (domestic guinea pig) |
|---|
| Description: | P41144 |
|---|
| Residue: | 380 |
|---|
| Sequence: | MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
|
|
|
|---|
| BDBM50551309 |
|---|
| n/a |
|---|
| Name | BDBM50551309 |
|---|
| Synonyms: | CHEMBL4758369 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H29NO4 |
|---|
| Mol. Mass. | 383.4807 |
|---|
| SMILES | [H][C@]12Oc3c4c(C[C@@]5([H])N(C)CC[C@]14C51C[C@]([H])(C(C)(C)O)[C@]2(OC)C=C1)ccc3O |r,c:29,TLB:3:4:12.11.9:14,27:5:12.11.9:14,4:13:16.15:25.26,12:13:16.15:25.26,THB:18:16:13.1:25.26| |
|---|
| Structure | 
|
|---|
Search and Browse
