Reaction Details |
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Target | 5'-nucleotidase |
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Ligand | BDBM18136 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2033446 (CHEMBL4687604) |
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Ki | 870±n/a nM |
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Citation | Jeffrey, JL; Lawson, KV; Powers, JP Targeting Metabolism of Extracellular Nucleotides via Inhibition of Ectonucleotidases CD73 and CD39. J Med Chem63:13444-13465 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5'-nucleotidase |
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Name: | 5'-nucleotidase |
Synonyms: | 5'-nucleotidase | 5NTD_RAT | Ecto-5'-nucleotidase (e5'NT) | Ecto-5-nucleotidase (e5'NT) | NT | Nt5 | Nt5e | Nte |
Type: | Enzyme |
Mol. Mass.: | 63971.44 |
Organism: | Rattus norvegicus (Rat) |
Description: | P21588 |
Residue: | 576 |
Sequence: | MRPAAATAPKWLLLALSALLPLWPTAKSWELTIMHTNDVHSRLEQTSDDSTKCLNASLCV
GGVARLFTKVQQIRKEEPNVLLLDAGDQYQGTIWFTVYKGLEVAHFMNLLGYDAMALGNH
EFDNGVEGLIDPLLRNVKFPILSANIKARGPLAPQISGLYLPYKVLSVGGEVVGIVGYTS
KETPFLSNPGTNLVFEDEVTALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDV
VVGGHTNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKVEFDDKG
NVVTSYGNPILLNSTIREDAAIKADINQWRIKLDNYSTQELGRTIVYLNGSAQECRFREC
NMGNLICDAMINNNLRHPDEMFWNHVSMCIVNGGGIRSPIDERNNGTITWENLAAVLPFG
GTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDISRKPWDRVVQLKVLCTK
CRVPIYEPLEMDKVYKVVLPSYLVNGGDGFQMIKDELLKHDSGDQDISVVSEYISKMKVI
YPAVEGRIKFSAASHYQGSFPLIILSFWAVILVLYQ
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BDBM18136 |
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n/a |
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Name | BDBM18136 |
Synonyms: | ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)methyl]phosphonic acid | alpha, beta-methyleneadenosine 5 -diphosphate | cid_92199 |
Type | Nucleoside or nucleotide |
Emp. Form. | C11H17N5O9P2 |
Mol. Mass. | 425.2283 |
SMILES | Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| |
Structure |
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